Structure of alanine racemase
WebThe structure of alanine racemase from B. stearothermophilus has been solved at 1.9 resolution. 74 The tertiary structure of the monomer consists of two domains: an eight-stranded α/β-barrel containing the pyridoxal phosphate cofactor, and a β-stranded C-terminal domain. The cofactor is covalently attached to Lys-39, which upon substrate ... WebSep 20, 1996 · The molecular structure of alanine racemase from Bacillus stearothermophilus was determined by X-ray crystallography to a resolution of 1.9 A. …
Structure of alanine racemase
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WebAlanine racemase catalyzes the interconversion of L- and D-alanine, the latter of which is an essential component in the peptidoglycan layer of the bacterial cell wall. The chemical transformation is illustrated in Scheme 3, which has been modeled by a combined QM/MM potential in molecular dynamics simulations. Sign in to download full-size image WebSep 15, 2024 · The U.S. Department of Energy's Office of Scientific and Technical Information
WebJul 28, 2015 · PDF Pyridoxal 5'-phosphate (PLP) dependent alanine racemase catalyzes racemization of L-Ala to D-Ala, a key component of the peptidoglycan network in... Find, read and cite all the research ... WebSep 14, 2004 · The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site PDB DOI: 10.2210/pdb1XFC/pdb Classification: ISOMERASE Organism (s): Mycobacterium tuberculosis Expression System: Escherichia coli BL21 Mutation (s): No Deposited: 2004 …
WebMay 12, 1998 · ALANINE RACEMASE COMPLEXED WITH ALANINE PHOSPHONATE PDB DOI: 10.2210/pdb1BD0/pdb Classification: ISOMERASE Organism (s): Geobacillus stearothermophilus Mutation (s): No Deposited: 1998-05-12 Released: 1998-10-14 Deposition Author (s): Stamper, G.F., Morollo, A.A., Ringe, D. Experimental Data Snapshot … WebApr 13, 2024 · The enzyme alanine racemase (Alr) has been a new target for the development of antibacterial drugs based on the involvement of D-Ala in bacterial cell wall …
Web历史. 1909年，Laschtschenko发现蛋清中有杀菌物质。1922年，亚历山大·弗莱明在研究鼻腔粘液的抗菌作用时发现并命名了溶菌酶。 1965年，大卫·菲利浦用X射线衍射技术研究溶菌酶晶体，解析出了2埃分辨率的晶体结构。 这是第二个使用X射线衍射技术得到的蛋白质结构，也是第一个解析出的酶结构。
WebStructure of DCS-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis great western manufacturing coWebFeb 8, 2005 · We report the crystal structure of alanine racemase from Mycobacterium tuberculosis (Alr(Mtb)) at 1.9 A resolution. In our structure, Alr(Mtb) is found to be a dimer formed by two crystallographically different monomers, each comprising 384 residues. The domain makeup of each monomer is similar to that of Bacillus and Pseudomonas alanine ... great western medical practice aberdeen newsflorida notary public application feeWebAug 26, 2016 · The structural homology and functional similarity between the two domains suggest that this enzyme evolved from an ancestral domain via gene duplication and gene fusion.. 2.3.2 The Catalytic Center of PLP-Independent Aspartate Racemase. The mutation of either Cys82 or Cys194 to alanine (C82A, C194A) markedly reduced the reaction rate … great western mfg co incWebJan 1, 2013 · Alanine racemase is present in many organisms and the structure determination of as many alanine racemases as possible will help in studying the … great western metals warehouseWebSep 12, 2013 · The 1.45 Å Crystal Structure of Alanine Racemase from a Pathogenic Bacterium, Pseudomonas aeruginosa. Contains both Internal and External Aldimine Structures Biochemistry, 2003, 42; 14752 2003 great western mining annual reportsWebFeb 26, 2024 · Alanine racemase (Alr) is a pyridoxal-5'-phosphate-dependent (PLP) enzyme that catalyzes a reversible racemization between the enantiomers of alanine. d-Alanine is … florida notary public commission