Web31 Mar 2010 · Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2JBax+/− mice exhibited complete resistance to nerve damage after 2 weeks (similar to Bax−/− mice), but … Web1 Jan 2001 · In the present study we investigated the expression of MMP-2 and MMP-9 (gelatinases A and B) during myelin removal after peripheral nerve trauma. After transection of the sciatic nerve an upregulation of MMP-2 and MMP-9 with a first peak 12 h and a second peak 48 h after axotomy was observed by zymography.
Dynamic changes in Robo2 and Slit1 expression in adult rat dorsal …
WebPeripheral nerve axotomy induces apoptosis in neonatal neurons supplying axons to the nerve. Bax is known to promote apoptosis among developing neurons. To examine the … Web24 May 2016 · The sciatic nerve sections, from mice submitted to nerve crushing, were incubated overnight at 4 °C in a moist chamber with goat anti-p75NTR (1:200, Santa Cruz … lahari resorts bhanur
(PDF) Sciatic nerve functional anatomy - ResearchGate
Web21 Aug 2024 · Nmrk2 mRNA was reported to be induced in PNS neurons after sciatic nerve axotomy . To investigate a potential induction of Nmrk2 after an excitotoxic insult in cortical neurons, Nmrk2 mRNA was quantified after 100 μM NMDA treatment for 24 h. We found a low induction of Nmrk2 transcript, but a 4-fold increase of Nmrk1 mRNA. Web15 Sep 2024 · Immature peripheral nervous system damage, such as the transection of a peripheral nerve, results in the extensive degeneration of motoneurons and dorsal root … WebThe left sciatic nerve was exposed, and axotomy was performed at “mid-thigh” level. A 5-mm portion of the nerve was resected to prevent regeneration. 23 For behavior study, the animals were allowed to survive for 7 days after surgery. For quantifying the number of DRG neurons, animals were allowed to survive for 1 month after axotomy. lahari resorts hyderabad packages