WebJul 29, 2003 · This isolate makes a novel family of wide spectrum peptide antibiotics called the munumbicins [1]. It represents the first antibiotic-producing endophytic streptomycete to be recovered from a woody plant [1]. WebApr 11, 2024 · Saccharothriolides Saccharothrix sp. Tsukamurella pulmonis Introduction The increasing demand for new bioactive natural products as lead compounds in drug discovery and as unique chemical tools has driven natural product chemists to develop approaches …
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WebFeb 13, 2024 · α,β-Unsaturated carbonyls are reactive group often found in bioactive small molecules. Their non-specific reaction with biomolecules can be the cause of the low efficacy and unexpected side-effects of the molecule. Accordingly, unprotected α,β-unsaturated carbonyls are not often found in drugs. WebJul 19, 2024 · Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. Lu S , Nishimura S , Hirai G , Ito M , Kawahara T , Izumikawa M , Sodeoka M , Shin-ya K , Tsuchida T , Kakeya H Chem Commun (Camb), 51 (38):8074-8077, 14 Apr 2015 Cited by: 3 articles PMID: 25869768
WebSep 17, 2024 · Saccharothriolides A-F are 10-membered microbial macrolides proposed to be generated from their precursors presaccharothriolides X-Z. Previously, we isolated … WebThe highly reactive precursor molecule, presaccharothriolide X, was successfully isolated from the rare actinomycete Saccharothrix sp. A1506. The comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating property of 2-aminophenol. Unexpectedly, 2-aminophenol in …
WebSep 1, 2015 · Saccharothriolide B (Ib) demonstrates moderate cytotoxicity against cancer cell lines HeLa and HT1080. Saccharothriolide B (Ib) demonstrates moderate cytotoxicity against cancer cell lines HeLa and HT1080.
WebSaccharothriolide B C25H31NO7 CID 134151810 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ...
WebApr 11, 2024 · The production of saccharothriolides was enhanced. A new derivative of saccharothriolides, saccharothriolide C 2 Abstract A combined-culture method was … black cat with blue eyes wallpaperWebThe comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating property of 2-aminophenol. Unexpectedly, 2-aminophenol in saccharothriolide B was eliminated through a retro-Michael reaction, to yield presaccharothriolide X under physiological conditions. 2 ... black cat with black stripesWebApr 11, 2024 · Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. Shan Lu, S. Nishimura, +7 authorsH. Kakeya Chemistry, Biology Chemical communications 2015 Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete … black cat with blue eyes meaningWebJul 22, 2016 · Saccharothriolide F (3) was identified to be a demethylated congener of saccharothriolides D (1) and A (4) at the C-2 position. The availability of compounds 1-6 enabled a structure-activity relationship study that revealed the importance of the phenolic hydroxy group at C-2″ and the stereochemistry of C-2 for the inhibition of human ... black cat with blue eyes namesWebSclareolide. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ?) Sclareolide is a sesquiterpene lactone natural product … gallon of diesel to kwhWebSaccharothriolide C2 C19H26O7 CID 146682103 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … gallon of d2WebJul 19, 2024 · Request PDF Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506 The highly reactive precursor ... gallon of chalk paint