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Rnf145

WebPrimePCR™ Template for SYBR® Green Assay: Rnf145, Rat Reaction: 4 billion copies/200 µl desalted Gene-specific synthetic DNA template designed to give a positive real-time PCR … WebOct 25, 2024 · Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER …

RNF145 Gene - Somatic Mutations in Cancer - Wellcome Sanger …

WebFeb 23, 2024 · Europe PMC is an archive of life sciences journal literature. WebDec 13, 2024 · RNF145 knockout cells stably reconstituted with RNF145-V5 (ΔR145 #4 + R145-V5, as shown in Figure 3—figure supplement 4C, lane 3) were sterol-depleted (SD, 20 hr) and, where indicated, sterols (S) added back for 1 hr in the presence of NMS-873 (10 µM, 1.5 hr). RNF145-V5 was affinity-purified (AP) and HMGCR detected by immunoblotting. flights from ohio to orlando florida https://gitamulia.com

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the ...

Weblxr还能上调idol和rnf145的表达，前者介导ldlr的降解，后者介导scap的降解。 此外，ACAT1和ACAT2可被过量的胆固醇变构激活，再连同LXR介导SREBP1c激活生成的脂肪 … WebAug 22, 2024 · RNF145's auto-ubiquitination and degradation are potently inhibited by unsaturated FAs (oleic, arachidonic or eicosapentaenoic acids), allowing RNF145 to … WebRNF145, a sterol-responsive ER-resident E3 ligase, is unstable but accumulates following sterol depletion. Sterol addition triggers RNF145 recruitment to HMGCR via Insigs, promoting HMGCR ubiquitination and proteasome-mediated degradation. In the absence of both RNF145 and gp78, Hrd1, a third flights from ohio to reno

RNF145 protein expression summary - The Human Protein Atlas

Category:RNF145 ubiquitinates SCAP to inhibit SREBP processing

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Rnf145

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a …

WebThe mouse Rnf145 cDNA was amplified from Hepa1-6 cells and cloned into expression plasmids by Gateway recombination (Invitrogen). The C537A mouse Rnf145 mutant was … WebJun 13, 2024 · The remaining ten CpG sites, located in DHCR24, CPT1A, RNF145, ASAM, KDM2B, MYO5C, TMEM49, ABCG1 (harboring two CpG sites) and the 4p15.33 region, are …

Rnf145

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WebRNF145. ring finger protein 145. UPS Project. GO Process (0) GO Function (0) GO Component (0) CRISPR Database HGNC Alliance of Genome Resources VEGA Entrez … WebRNF145, a sterol-responsive ER-resident E3 ligase, is unstable but accumulates following sterol depletion. Sterol addition triggers RNF145 recruitment to HMGCR via Insigs, …

WebFeb 23, 2024 · Regulation of RNF145 by LXR depends on a functional LXR-element in its proximal promotor. Consistent with LXR-dependent regulation of Rnf145 we show that … WebOur RNF145 polyclonal antibodies are developed in Rabbit. Find the RNF145 antibody that fits your needs. Choose from 1 of 2 RNF145 antibodies, which have been validated in …

WebNM_001199383.2(RNF145):c.1297T>A (p.Leu433Ile) Cite this record. Cite this record Close. Copy. Help Interpretation: Uncertain significance Review status: criteria provided, single submitter Submissions: 1 First in ... WebHuman pathology. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. RNF145.

WebApr 8, 2024 · Somatic mutations in non-coding regions of the genome and even exonic mutations may have unidentified non-coding consequences which are often overlooked in analysis workflows. Here we present RegTools ([www.regtools.org][1]), a free, open-source software package designed to integrate analysis of somatic variant calls from genomic …

WebPredicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to … cherokee reserve canton gaWebThe gene view histogram is a graphical view of mutations across RNF145. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict … cherokee reservation in oklahomacherokee reservations in usaWebRNF145 ubiquitinates SCAP to inhibit SREBP processing. (A) CHO cells were transfected with plasmids encoding HSV-tagged SCAP and HAtagged ubiquitin, together with RNF145 … flights from ohio to rhode islandWebBy using this site, you agree to our Terms and Conditions Got it! cherokee reservation oklahoma mapWebRNF145 (FLJ31951) protein expression summary. E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific s ubstrate. … cherokee reservation north carolinaWebDec 13, 2024 · In particular, RNF145 builds up when a cell is starved of cholesterol, but it immediately marks HMGCR for destruction once cholesterol becomes more abundant. … cherokee reserve community association inc