Oxazaphosphorine
Webother oxazaphosphorine cytostatics like Ifosfamide (IF). The enzymatic cleavage of ALDO to form PAM and HPA is important for another reason that makes CP exceptional as an alkylating cytostatic. HPA - which becomes acrolein by elimination of water - is a pro-apoptotic aldehyde that promotes apoptosis by inhibiting the anti- WebCyclophosphamide Synonyms: Cyclophosphamide monohydrate, 2- [Bis (2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan Empirical Formula (Hill Notation): C7H15Cl2N2O2P · H2O CAS Number: 6055-19-2 Molecular Weight: 279.10 Product Comparison Guide Use the product attributes below to configure the …
Oxazaphosphorine
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WebIntratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy. In: Walden, P., Trefzer, U., Sterry, W., … WebJan 30, 2009 · P-Stereogenic oxazaphosphorine compounds of the form 4 have not previously been reported as asymmetric ligands for metal-catalyzed reactions. In an effort to explore the behavior of such oxazaphosphorine ligands, monomeric oxazaphosphorine borane 9 and dimeric oxazaphosphorine boranes 25 and 26 were synthesized as catalyst …
WebThe oxazaphosphorines cyclophosphamide, ifosfamide and trofosfamide remain a clinically useful class of anticancer drugs with substantial antitumour activity against a variety of … WebApr 1, 2015 · For intermittent oxazaphosphorine therapy. Oral administration of 40% of the dosage of the oxazaphosphorine on a weight for weight basis rounded down to the …
WebThe oxazaphosphorine cyclophosphamide is one of the most widely used drugs in cancer chemotherapy. It is also used as an immunosuppressive at lower doses. As with the other anticancer drugs discussed in previous sessions, it is a prodrug. WebOxazaphosphorine metabolism is affected by a number of factors associated with the drugs (e.g., dosage, route of administration, chirality, and drug combination) and patients (e.g., age, gender, renal and hepatic function). Several drug transporters, such as breast cancer resistance protein (BCRP), multidrug resistance associated proteins (MRP1 ...
WebNov 10, 2024 · Mesna (sodium 2-mercaptoethane sulfonate) is a detoxifying agent used to prevent hemorrhagic cystitis in patients receiving chemotherapy with either high-dose cyclophosphamide or ifosfamide.
WebTetrahydro-2-(bis(2-chloroethyl)amino)-3-methyl-2H-1,3,2-oxazaphosphorine 2-oxide C8H17Cl2N2O2P CID 211031 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. terra kendama shapesWebthe failed attempt to improve oxazaphosphorine cytostatics (OX) is the development of Glufosfamide ( -D-glucose-isophosphoreamide mustard), which has been synthesized on the basis of the rationale terrakhanaWebBackground: Oxazaphosphorines (cyclophosphamide (CPA), ifosfamide (IFO)) are major alkylating agents of polychemotherapy protocols but limiting their toxicity and increasing … terra khayaWebApr 1, 2015 · For intermittent oxazaphosphorine therapy following an initial intravenous injection of mesna at a dose of 20% (w/w) of the oxazaphosphorine dose, oral mesna (40% w/w) should be administered at 2 hours and again at 6 hours after the initial intravenous dose. Alternatively, three oral doses of mesna may be administered, replacing the i.v. dose … terra kh ageWebCyclophosphamide monohydrate. undefined. Synonyms: 2-[Bis(2-chloroethyl)amino]tetrahydro-2 H -1,3,2-oxazaphosphorine 2-oxide, Cytoxan. CAS 6055-19-2. Molecular Weight 279.10. Browse Cyclophosphamide monohydrate … terra kh3WebCyclophosphamide ( CP ), also known as cytophosphane among other names, [3] is a medication used as chemotherapy and to suppress the immune system. [4] As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. [4] terra kh2WebSep 1, 1983 · The development of stabilised primary metabolites of the oxazaphosphorine cytostatics (8) and the solution of the problem of organ-specific detoxification with … terra kh wiki