2024 Haplotype-resolved genome assemblies

Haplotype-resolved genome assemblies

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August undefined, 2024

WebJun 9, 2024 · and Hi-C scaﬀolding, we present a high-quality, haplotype-resolved genome assembly. The genome size was 740.2 Mb, with a contig N50 size of 5.47 Mb and a scaﬀold N50 size of 46.68 Mb ... WebHere, we report a high-quality haplotype-resolved genome of B. striata, haplotype A (2.37 Gb, with a scaffold N50 of 146.39 Mb and a contig N50 of 1.65 Mb) and haplotype B …

(PDF) Multi-platform discovery of haplotype-resolved structural ...

WebApr 19, 2024 · ABSTRACT Haplotype-resolved genome assemblies are important for understanding how combinations of variants impact phenotypes. These assemblies can be created in various ways, such as use of tissues that contain single-haplotype (haploid) genomes, or by co-sequencing of parental genomes, but these approaches can be … WebAug 5, 2024 · High-quality, haplotype-resolved genome assembly and allele-specific gene expression data may provide further insights into the origin and evolution of traits specific to cultivated ginger. Here, we report a chromosome-scale haplotype-resolved genome assembly of “Zhangliang” ginger, a landrace passed down from the Chinese Han … paul mccobb credenza

T2T单倍型（Haplotype-resolved T2T）基因组全套解决方案（完 …

WebFeb 1, 2024 · Haplotype-resolved de novo assembly is the ultimate solution to the study of sequence variations in a genome. However, existing algorithms either collapse heterozygous alleles into one... We would like to show you a description here but the site won’t allow us. WebHaplotype-resolved de novo assembly is the ultimate solution to the study of sequence variations in a genome. However, existing algorithms either collapse heterozygous … WebApr 13, 2024 · Human mtDNA is a circular genome containing 37 genes, encoding 13 proteins and a noncoding D-loop region. Heteroplasmic mutations, inherited from egg cells, can cause congenital diseases, like ... paul mccobb designer

Chromosome-Scale, Haplotype-Resolved Genome …

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WebNov 17, 2024 · Assembled sequences representing alternative haplotypes covered 70.3–95.1% of the genomes, suggesting that the four coniferous tree genomes exhibit high heterozygosity levels. The genome sequence information obtained in this study represents a milestone in tree genetics and genomics, and will facilitate gene discovery, allele … WebDec 29, 2024 · Generating chromosome-level, haplotype-resolved assemblies of heterozygous genomes remains challenging. To address this, we developed gamete binning, a method based on single-cell sequencing of haploid gametes enabling separation of the whole-genome sequencing reads into haplotype-specific reads sets. paul mccobb ottomanWebDec 29, 2024 · Generating chromosome-level, haplotype-resolved assemblies of heterozygous genomes remains challenging. To address this, we developed gamete binning, a method based on single-cell sequencing of haploid gametes enabling separation of the whole-genome sequencing reads into haplotype-specific reads sets. After … paul mccobb rattan bar stool

"WebHaplotype-resolved genome assembly provides insights into evolutionary history of the tea plant. Here, we present a haplotype-resolved assembly of an Oolong tea cultivar, Tieguanyin. Analysis of allele-specific expression suggests a potential mechanism in response to mutation load during long-term clonal propagation. " - Haplotype-resolved genome assemblies

Haplotype-resolved genome assemblies

Haplotype-resolved de novo genome assemblies of four …

WebWe present 64 assembled haplotypes from 32 diverse human genomes. These highly contiguous haplotype assemblies (average minimum contig length needed to cover … WebOct 27, 2024 · Haplotype-aware diploid genome assembly is crucial in genomics, precision medicine, and many other disciplines. Long-read sequencing technologies have greatly improved genome assembly. However, current long-read assemblers are either reference based, so introduce biases, or fail to capture the haplotype diversity of diploid genomes. …

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WebNov 17, 2024 · Assembled sequences representing alternative haplotypes covered 70.3-95.1% of the genomes, suggesting that the four coniferous tree genomes exhibit high heterozygosity levels. The genome sequence ... WebJan 4, 2024 · Overview of the haplotype-resolved genome assembly of the “Yanli” (Fragaria × ananassa) genome. The tracks (moving inwards) indicate the distribution of …

WebDec 29, 2024 · We assemble the two genomes of a diploid apricot tree based on whole-genome sequencing of 445 individual pollen grains. The two haplotype assemblies … WebMar 24, 2024 · Routine haplotype-resolved genome assembly from single samples remains an unresolved problem. Here we describe an algorithm that combines PacBio …

WebApr 10, 2024 · Moreover, accuracy of QTL mapping and genome-wide associations studies greatly benefit from a haplotype-resolved dataset 24,25, in particular, to identify structural variation 26,27. WebMar 24, 2024 · The haplotype-resolved assembly is, thus, reduced to the unitig phasing problem (Supplementary Fig. 1). Producing a dual assembly with HiFi reads only Recall …

WebNov 8, 2024 · Here, we present a reference genome of the Nile rat, the first high-quality diurnal rodent genome with two complete haplotype-resolved parental genome assemblies. The assemblies are represented by …

WebFeb 14, 2024 · The lemon (Citrus limon; family Rutaceae) is one of the most important and popular fruits worldwide.Lemon also tolerates huanglongbing (HLB) disease, which is a devastating citrus disease. Here we produced a gap-free and haplotype-resolved chromosome-scale genome assembly of the lemon by combining Pacific Biosciences … paul mccobb origami chairWeb1 day ago · The ultimate goal of genome 40 assembly is a haplotype-resolved gap-free genome, which opens up new possibilities for 41 the discovery of distinct genes and structural variants in the "dark matter" areas, like 42 centromeres, transposable elements, and segmental duplications that are often difficult 43 to detect and study using traditional ... paul mccolgan deloitteWebApr 29, 2024 · Inbred animals were historically chosen for genome analysis to circumvent assembly issues caused by haplotype variation but this resulted in a composite of the two genomes. Here we report a haplotype-aware scaffolding and polishing pipeline which was used to create haplotype-resolved, chromosome-lev … paul mccobb rattan chairWebJan 23, 2024 · Constructing high-quality haplotype-resolved genome assemblies has substantially improved the ability to detect and characterize genetic variants. A targeted approach providing readily access to the rich information from haplotype-resolved genome assemblies will be appealing to groups of basic researchers and medical scientists … paul mccobb stangl ceramic dishWebNov 5, 2024 · Here, we characterize 273 of these 395 challenging autosomal genes using a haplotype-resolved whole-genome assembly. This curated benchmark reports over 17,000 single-nucleotide variations, 3,600 ... paul mccomas fatal crashWeb12 hours ago · With the advent of accurate long reads from PacBio HiFi, haplotype-resolved (or ‘diploid’) assembly across much of the genome became possible 9,25,46,49,100 and, combined with new methods ... paul mccomiskey podiatristWebTelomere-to-telomere genome assemblies for two kiwifruit species, Actinidia latifolia and Actinidia chinensis, were constructed from HiFi and Hi-C reads. Extensive comparative genomics analyses of the transcriptome … paul mccomas