WebCrystal Pharmatech has been providing world-leading solid state research and formulation CDMO services to global pharmaceutical companies since 2010. We use Molecule-Material-Medicine (MMM) approach to develop … WebJun 25, 2024 · Laboratory evaluation consists of exposing thin layers of the drug or excipient on dishes at a variety of relative humidities (RH) and at different temperatures; measuring the weight gain or loss over a few days or weeks of exposure and hence the amount of water taken up under each specific temperature and humidity condition.
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WebUCB is a global biopharmaceutical company focused on creating value for people living with severe diseases that have significant unmet needs. By putting people at the heart of … WebJan 1, 2024 · Crystal Structure Cocrystal 1 crystallizes in the triclinic space group P-1 and contains one pentoxifylline, one dihydromyricetin, and one water molecule in the asymmetric unit. As expected, there exist versatile hydrogen-bonding interactions between dihydromyricetin and pentoxifylline. buisson japonaise
Cocrystals of diacerein: Towards the development of improved ...
WebDec 15, 2024 · As a strong Lewis acid, zinc ion (Zn 2+) exists in several coordination geometries. Fig. 1 shows four zinc-organic crystal structures with coordination numbers of 3, 4, 5, and 6. The CSD has long been considered an invaluable resource for drug discovery and drug development because it can provide structural knowledge, particularly about … WebJan 25, 2024 · The present study demonstrates cocrystallization as a successful technique to improve the biopharmaceutical parameters of diacerein. Three cocrystals of diacerein were prepared by an eco-friendly technique with three suitable coformers namely isonicotinamide, nicotinamide, and theophylline. The formation of a new solid phase was … WebMar 22, 2024 · The crystal structure was determined from single crystal and PXRD that exposed the existence of the monoclinic and triclinic crystal system with P21/n and P-1 space groups. The dermatokinetic studies on the rat skin revealed two- to threefold improvement in relative bioavailability as compared to pure 5-FU. buisson-battault